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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">pediatricjournal</journal-id><journal-title-group><journal-title xml:lang="ru">Архив педиатрии и детской хирургии</journal-title><trans-title-group xml:lang="en"><trans-title>Archives of Pediatrics and Pediatric Surgery</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2949-4664</issn><issn pub-type="epub">3033-6783</issn><publisher><publisher-name>НИКИ детства Минздрава Московской области</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.31146/2949-4664-apps-2-3-49-58</article-id><article-id custom-type="elpub" pub-id-type="custom">pediatricjournal-111</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОР ЛИТЕРАТУРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEW</subject></subj-group></article-categories><title-group><article-title>Бронхолегочная дисплазия: некоторые патофизиологические аспекты</article-title><trans-title-group xml:lang="en"><trans-title>Bronchopulmonary dysplasia: some pathophysiological aspects</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3043-8674</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лошкова</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Loshkova</surname><given-names>E. V.</given-names></name></name-alternatives><email xlink:type="simple">loshkova.ev@ssmu.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2048-1852</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Люлька</surname><given-names>Т. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Lyulka</surname><given-names>T. S.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0747-5952</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дорошенко</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Doroshenko</surname><given-names>I. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0008-7135-7361</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Будкин</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Budkin</surname><given-names>A. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3281-803X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рафикова</surname><given-names>Ю. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Rafikova</surname><given-names>Yu. S.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3241-282X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Терентьева</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Terentieva</surname><given-names>A. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5792-2012</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Янкина</surname><given-names>Г. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Yankina</surname><given-names>G. N.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2133-665X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Желев</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Zhelev</surname><given-names>V. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4439-151X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Михалев</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Mikhalev</surname><given-names>E. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-4"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">Федеральное Государственное Бюджетное Образовательное Учреждение Высшего Образования «Сибирский государственный медицинский университет» Министерства здравоохранения Российской Федерации; Научно-исследовательский клинический институт детства Министерства здравоохранения Московской области, Москва, Российская Федерация; ФГБНУ «Медико-генетический научный центр имени академика Н.П. Бочкова»<country>Россия</country></aff><aff xml:lang="en">Siberian state medical University; Research Clinical Institute of Childhood, Ministry of Health of the Moscow Region; Federal state budgetary scientific institution Medical Genetic Research Center named after Academican N.P. Bochkov<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru">Федеральное Государственное Бюджетное Образовательное Учреждение Высшего Образования «Санкт-Петербургский государственный педиатрический медицинский университет» Министерства здравоохранения Российской Федерации<country>Россия</country></aff><aff xml:lang="en">Saint-Petersburg State Pediatric Medical University<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru">ОГКУЗ «Областной дом ребенка»<country>Россия</country></aff><aff xml:lang="en">Regional State Healthcare Institution “Regional Children’s Home”<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru">Федеральное Государственное Бюджетное Образовательное Учреждение Высшего Образования «Сибирский государственный медицинский университет» Министерства здравоохранения Российской Федерации<country>Россия</country></aff><aff xml:lang="en">Siberian state medical University<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>03</day><month>02</month><year>2025</year></pub-date><volume>2</volume><issue>3</issue><fpage>49</fpage><lpage>58</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Лошкова Е.В., Люлька Т.С., Дорошенко И.В., Будкин А.В., Рафикова Ю.С., Терентьева А.А., Янкина Г.Н., Желев В.А., Михалев Е.В., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Лошкова Е.В., Люлька Т.С., Дорошенко И.В., Будкин А.В., Рафикова Ю.С., Терентьева А.А., Янкина Г.Н., Желев В.А., Михалев Е.В.</copyright-holder><copyright-holder xml:lang="en">Loshkova E.V., Lyulka T.S., Doroshenko I.V., Budkin A.V., Rafikova Y.S., Terentieva A.A., Yankina G.N., Zhelev V.A., Mikhalev E.V.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.nikid.ru/jour/article/view/111">https://journal.nikid.ru/jour/article/view/111</self-uri><abstract><p>В настоящем обзоре будут рассмотрены факторы риска развития и патофизиологические механизмы повреждения легких при бронхолегочной дисплазии, как ведущие звенья формирования многофакторной этиологии данного заболевания. Понимание многофакторности этиологии БЛД и механизмов повреждения легочной ткани позволит фундаментально обосновать фенотипическую гетерогенность заболевания для разработки персонализированных подходов к профилактике и терапии.</p></abstract><trans-abstract xml:lang="en"><p>This review will consider risk factors for the development and pathophysiological mechanisms of lung injury as leading links in the formation of multifactorial etiology. Understanding the multifactorial etiology of BPD and the mechanisms of damage to lung tissue will make it possible to fundamentally substantiate the phenotypic heterogeneity of the disease for the development of personalized approaches to prevention and therapy.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>бронхолегочная дисплазия</kwd><kwd>респираторная поддержка</kwd><kwd>недоношенный ребенок</kwd><kwd>факторы риска</kwd><kwd>кислород</kwd><kwd>воспаление</kwd><kwd>аутофагия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>bronchopulmonary dysplasia</kwd><kwd>respiratory support</kwd><kwd>premature</kwd><kwd>risk factors</kwd><kwd>oxygen</kwd><kwd>inflammation</kwd><kwd>autophagy</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Schmidt A.R., Ramamoorthy C. Bronchopulmonary dysplasia. 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