pediatricjournalАрхив педиатрии и детской хирургииArchives of Pediatrics and Pediatric Surgery2949-46643033-6783НИКИ детства Минздрава Московской области10.66825/2949-4664-apps-3-3-73-80pediatricjournal-234Research ArticleОБЗОР ЛИТЕРАТУРЫLITERATURE REVIEWПредикция снижения частоты внутрижелудочковых кровоизлияний у глубоконедоношенных детей. Литературный обзорPrediction of a decrease in neonatal intraventricular hemorrhage incidence in very premature infants. Literature reviewНефедоваЕ. М.NefedovaE. M.

Нефедова Екатерина Михайловна, врач — анестезиолог-реаниматолог отделения реанимации и интенсивной терапии новорожденных 

шоссе Энтузиастов, д. 12, г. Балашиха, 143900

12 Entuziastov Highway, Balashikha, 143900

https://orcid.org/0000-0002-8020-2598ПетроваА. С.PetrovaA. S.

Петрова Анастасия Сергеевна, к.м.н., доцент, ведущий научный сотрудник отдела неонатальной медицины и огнитивного развития; заместитель главного врача по педиатрической части

шоссе Энтузиастов, д. 12, г. Балашиха, 143900; ул. Коминтерна, д. 24А, стр. 1, г. Мытищи, 141009

12 Entuziastov Highway, Balashikha, 143900; 24A Kominterna str., building 1, Mytishchi, Moscow region, 141009

https://orcid.org/0000-0001-7215-2212ЗахароваН. И.ZakharovaN. I.

Захарова Нина Ивановна, д.м.н., профессор, руководитель отдела неонатальной медицины и когнитивного развития 

ул. Коминтерна, д. 24А, стр. 1, г. Мытищи, 141009

24A Kominterna str., building 1, Mytishchi, Moscow region, 141009

https://orcid.org/0000-0002-2214-1336ЛаврентьевС. Н.LavrentievS. N.

Лаврентьев Сергей Николаевич, научный сотрудник отдела неонатальной медицины и когнитивного развития 

шоссе Энтузиастов, д. 12, г. Балашиха, 143900; ул. Коминтерна, д. 24А, стр. 1, г. Мытищи, 141009

12 Entuziastov Highway, Balashikha, 143900; 24A Kominterna str., building 1, Mytishchi, Moscow region, 141009

https://orcid.org/0000-0003-4531-1323КондратьевМ. В.KondratievM. V.

Кондратьев Максим Васильевич, врач—анестезиолог-реаниматолог, заведующий отделением реанимации и интенсивной терапии новорожденных; научный сотрудник отдела неонатальной медицины и когнитивного развития

шоссе Энтузиастов, д. 12, г. Балашиха, 143900; ул. Коминтерна, д. 24А, стр. 1, г. Мытищи, 141009

12 Entuziastov Highway, Balashikha, 143900; 24A Kominterna str., building 1, Mytishchi, Moscow region, 141009

https://orcid.org/0000-0003-1408-6450ГрызуноваА. С.GryzunovaA. S.

Грызунова Анастасия Сергеевна, врач — анестезиолог-реаниматолог; научный сотрудник отдела неонатальной медицины и когнитивного развития 

шоссе Энтузиастов, д. 12, г. Балашиха, 143900; ул. Коминтерна, д. 24А, стр. 1, г. Мытищи, 141009

12 Entuziastov Highway, Balashikha, 143900; 24A Kominterna str., building 1, Mytishchi, Moscow region, 141009

ПоздняковаМ. А.PozdnyakovaM. A.

Позднякова Мария Александровна, научный сотрудник отдела неонатальной медицины и когнитивного развития 

шоссе Энтузиастов, д. 12, г. Балашиха, 143900; ул. Коминтерна, д. 24А, стр. 1, г. Мытищи, 141009

12 Entuziastov Highway, Balashikha, 143900; 24A Kominterna str., building 1, Mytishchi, Moscow region, 141009

https://orcid.org/0000-0001-7225-2053МалютинаЛ. В.MalyutinaL. V.

Малютина Людмила Вячеславовна, к.м.н., доцент, ведущий научный сотрудник отдела неонатальной медицины и когнитивного развития; заместитель главного врача 

ул. Коминтерна, д. 24А, стр. 1, г. Мытищи, 14100; ул. Парковая, д. 6, г. Щелково, 141100

24A Kominterna str., building 1, Mytishchi, Moscow region, 141009; 6 Parkovaya str., Shchelkovo

ГБУЗ МО «Московский областной перинатальный центр Министерства здравоохранения Московской области»Moscow Regional Perinatal Center of the Ministry of Health of the Moscow RegionГБУЗ МО «Московский областной перинатальный центр Министерства здравоохранения Московской области»; ГБУЗ МО «Научно-исследовательский клинический институт детства Министерства здравоохранения Московской области»Moscow Regional Perinatal Center of the Ministry of Health of the Moscow Region; Scientific Research Clinical Institute of Childhood of the Ministry of Health of the Moscow RegionГБУЗ МО «Научно-исследовательский клинический институт детства Министерства здравоохранения Московской области»Scientific Research Clinical Institute of Childhood of the Ministry of Health of the Moscow RegionГБУЗ МО «Московский областной перинатальный центр Министерства здравоохранения Московской области»; ГБУЗ МО «Научно-исследовательский клинический институт детства Министерства здравоохранения Московской области»Moscow Regional Perinatal Center of the Ministry of Health of the Moscow Region; Scientific Research Clinical Institute of Childhood of the Ministry of Health of the Moscow RegionГБУЗ МО «Научно-исследовательский клинический институт детства Министерства здравоохранения Московской области»; ГБУЗ МО «Щелковский перинатальный центр Министерства здравоохранения Московской области»Scientific Research Clinical Institute of Childhood of the Ministry of Health of the Moscow Region; Shchelkovsky Perinatal Center of the Ministry of Health of the Moscow Region202526122025337380Copyright © Нефедова Е.М., Петрова А.С., Захарова Н.И., Лаврентьев С.Н., Кондратьев М.В., Грызунова А.С., Позднякова М.А., Малютина Л.В., 20252025Нефедова Е.М., Петрова А.С., Захарова Н.И., Лаврентьев С.Н., Кондратьев М.В., Грызунова А.С., Позднякова М.А., Малютина Л.В.Nefedova E.M., Petrova A.S., Zakharova N.I., Lavrentiev S.N., Kondratiev M.V., Gryzunova A.S., Pozdnyakova M.A., Malyutina L.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.nikid.ru/jour/article/view/234

Внутрижелудочковое кровоизлияние (ВЖК) относится к частым поражениям головного мозга у недоношенных новорожденных, приводящим к нарушению неврологического развитии и увеличению смертности [1–3]. ВЖК — мультифакторное заболевание, одним из факторов которого является нестабильный кровоток в головном мозге недоношенного ребенка [4]. Несмотря на улучшение условий и технологий выхаживания недоношенных детей, повышение выживаемости детей с очень низкой массой тела (ОНМТ) и экстремально низкой массой тела (ЭНМТ) при рождении, частота ВЖК не меняется [4]. У детей с ОНМТ ВЖК развивается в 20–25% случаев, тогда как для детей с ЭНМТ при рождении такой процент возрастает до 45 [5]. В литературном обзоре обсуждаются алгоритмы и пути профилактики данного осложнения.

Neonatal intraventricular hemorrhage (IVH) is a frequent condition in premature newborns associated with brain damage, leading to impaired neurological development of the child [1–3]. IVH is a multifactorial condition, with one of the factors being unstable blood flow in the brain of a premature infant [4]. Despite the emergence of improved technologies in neonatal care and an increase in the survival rate of infants with very low body weight (VLBW) and extremely low body weight (ELBW) at birth, the incidence of IVH remains virtually at the same level [4]. In children with VLBW, IVH develops in 20–25% of cases, whereas in children with ELBW at birth, this share increases to 45% [5]. The presented literature review discusses algorithms and approaches to preventing this complication.

недоношенные новорожденныевнутрижелудочковые кровоизлияниякровоток головного мозгадоплерографияpremature newbornsintraventricular hemorrhagescerebral blood flowdopplerographyReferencesCizmeci M.N., de Vries L.S., Ly L.G., van Haastert I.C., Groenendaal F., Kelly E.N., et al. Periventricular hemorrhagic infarction in very preterm infants: characteristic sonographic findings and association with neurodevelopmental outcome at age 2 years. J Pediatr. 2020;217:1–7. doi: 10.1016/j.jpeds.2019.09.081.Cizmeci M.N., de Vries L.S., Ly L.G., van Haastert I.C., Groenendaal F., Kelly E.N., et al. Periventricular hemorrhagic infarction in very preterm infants: characteristic sonographic findings and association with neurodevelopmental outcome at age 2 years. J Pediatr. 2020;217:1–7. doi: 10.1016/j.jpeds.2019.09.081.Patra K., Wilson-Costello D., Taylor H.G., Mercuri-Minich N., Hack M. Grades I–II intraventricular hemorrhage in extremely low birth weight infants: effects on neurodevelopment. The Journal of pediatrics. 2006;149:169–73. doi: 10.1016/j.jpeds.2006.04.002.Patra K., Wilson-Costello D., Taylor H.G., Mercuri-Minich N., Hack M. Grades I–II intraventricular hemorrhage in extremely low birth weight infants: effects on neurodevelopment. The Journal of pediatrics. 2006;149:169–73. doi: 10.1016/j.jpeds.2006.04.002.Bolisetty S., Dhawan A., Abdel-Latif M., Bajuk B., Stack J., Lui K., et al. Intraventricular hemorrhage and neurodevelopmental outcomes in extreme preterm infants. Pediatrics. 2014;133:55–62. doi: 10.1542/peds.2019-2079.Bolisetty S., Dhawan A., Abdel-Latif M., Bajuk B., Stack J., Lui K., et al. Intraventricular hemorrhage and neurodevelopmental outcomes in extreme preterm infants. Pediatrics. 2014;133:55–62. doi: 10.1542/peds.2019-2079.Hwang-Bo S., Seo Y.M., Oh M.Y., Im S.A., Youn Y.A. The prognosis of refract oryhypotension and severe intraventricular hemorrhage in very low birth weight infants. Medicine (Baltimore). 2022;101(30): e29598. doi: 10.1097/MD.0000000000029598.Hwang-Bo S., Seo Y.M., Oh M.Y., Im S.A., Youn Y.A. The prognosis of refract oryhypotension and severe intraventricular hemorrhage in very low birth weight infants. Medicine (Baltimore). 2022;101(30): e29598. doi: 10.1097/MD.0000000000029598.Perlman J.M. Periventricular-intraventricular hemorrhage in the premature infant — a historical perspective. Semin Perinatol. 2022;46(5):1–8. doi: 10.1016/j.semperi. 2022.151591.Perlman J.M. Periventricular-intraventricular hemorrhage in the premature infant — a historical perspective. Semin Perinatol. 2022;46(5):1–8. doi: 10.1016/j.semperi. 2022.151591.Noori S., Seri I. Hemodynamic antecedents of peri/ intraventricular hemorrhage in very preterm neonates. Semin Fetal Neonatal Med. 2015;20(4):232–237. doi: 10.1016/j.siny.2015.02.004.Noori S., Seri I. Hemodynamic antecedents of peri/ intraventricular hemorrhage in very preterm neonates. Semin Fetal Neonatal Med. 2015;20(4):232–237. doi: 10.1016/j.siny.2015.02.004.Pei-Chen Tsao Pathogenesis and Prevention of Intraventricular Hemorrhage in Preterm Infants. J Korean Neurosurg Soc. 2023;66(3):228–238. doi: 10.3340/jkns.2022.0288.Pei-Chen Tsao Pathogenesis and Prevention of Intraventricular Hemorrhage in Preterm Infants. J Korean Neurosurg Soc. 2023;66(3):228–238. doi: 10.3340/jkns.2022.0288.Menke J., Michel E., Rabe H., Bresser B.W., Grohs B., Schmitt R.M., et al. Simultaneous influence of blood pressure, PCO2, and PO2 on cerebral blood flow velocity in preterm infants of less than 33 weeks’ gestation. Pediatr Res. 1993;34(2):173–7. doi: 10.1203/00006450-199308000-00014.Menke J., Michel E., Rabe H., Bresser B.W., Grohs B., Schmitt R.M., et al. Simultaneous influence of blood pressure, PCO2, and PO2 on cerebral blood flow velocity in preterm infants of less than 33 weeks’ gestation. Pediatr Res. 1993;34(2):173–7. doi: 10.1203/00006450-199308000-00014.Farag M.M., Gouda M.H., Almohsen A.M.A., Khalifa M.A. Intraventricular hemorrhage prediction in premature neonates in the era of hemodynamics monitoring: a prospective cohort study. Eur J Pediatr. 2022;181(12):4067–77. doi: 10.1007/s00431-022-04630-5.Farag M.M., Gouda M.H., Almohsen A.M.A., Khalifa M.A. Intraventricular hemorrhage prediction in premature neonates in the era of hemodynamics monitoring: a prospective cohort study. Eur J Pediatr. 2022;181(12):4067–77. doi: 10.1007/s00431-022-04630-5.Kooi E.M.W., Richter A.E. Cerebral autoregulation in sick infants: current insights. Clin Perinatol. 2020;47:449–467. doi: 10.1016/j.clp.2020.05.003.Kooi E.M.W., Richter A.E. Cerebral autoregulation in sick infants: current insights. Clin Perinatol. 2020;47:449–467. doi: 10.1016/j.clp.2020.05.003.Kooi E.M.W., Verhagen E.A., Elting J.W.J., Czosnyka M., Austin T., Wong F.Y., et al. Measuring cerebrovascular autoregulation in preterm infants using near-infrared spectroscopy: an overview of the literature. Expert Rev Neurother. 2017;17:801–818. doi: 10.1080/14737175.2017.1346472.Kooi E.M.W., Verhagen E.A., Elting J.W.J., Czosnyka M., Austin T., Wong F.Y., et al. Measuring cerebrovascular autoregulation in preterm infants using near-infrared spectroscopy: an overview of the literature. Expert Rev Neurother. 2017;17:801–818. doi: 10.1080/14737175.2017.1346472.Panerai R.B., Kelsall A.W., Rennie J.M., Evans D.H. Cerebral autoregulation dynamics in premature newborns. Stroke. 1995;26:74–80. doi: 10.1161/01.str.26.1.74.Panerai R.B., Kelsall A.W., Rennie J.M., Evans D.H. Cerebral autoregulation dynamics in premature newborns. Stroke. 1995;26:74–80. doi: 10.1161/01.str.26.1.74.Soul J.S., Hammer P.E., Tsuji M., Saul J.P., Bassan H., Limperopoulos C., Disalvo D.N., Moore M., Akins P., Ringer S., Volpe J.J., Trachtenberg F., du Plessis A.J. Fluctuating pressure-passivity is common in the cerebral circulation of sick premature infants. Pediatr Res. 2007 Apr;61(4):467–73. doi: 10.1203/pdr.0b013e31803237f6. PMID: 17515873.Soul J.S., Hammer P.E., Tsuji M., Saul J.P., Bassan H., Limperopoulos C., Disalvo D.N., Moore M., Akins P., Ringer S., Volpe J.J., Trachtenberg F., du Plessis A.J. Fluctuating pressure-passivity is common in the cerebral circulation of sick premature infants. Pediatr Res. 2007 Apr;61(4):467–73. doi: 10.1203/pdr.0b013e31803237f6. PMID: 17515873.Thewissen L., Naulaers G., Hendrikx D., Caicedo A., Barrington K., Boylan G., et al. Cerebral oxygen saturation and autoregulation during hypotension in extremely preterm infants. Pediatr Res. 2021;90:373–380. doi: 10.1038/s41390-021-01483-W.Thewissen L., Naulaers G., Hendrikx D., Caicedo A., Barrington K., Boylan G., et al. Cerebral oxygen saturation and autoregulation during hypotension in extremely preterm infants. Pediatr Res. 2021;90:373–380. doi: 10.1038/s41390-021-01483-W.Tsuji M., Saul J.P., du Plessis A., Eichenwald E., Sobh J., Crocker R., et al. Cerebral intravascular oxygenation correlates with mean arterial pressure in critically ill premature infants. Pediatrics. 2000;106:625–632. doi: 10.1542/peds.106.4.625.Tsuji M., Saul J.P., du Plessis A., Eichenwald E., Sobh J., Crocker R., et al. Cerebral intravascular oxygenation correlates with mean arterial pressure in critically ill premature infants. Pediatrics. 2000;106:625–632. doi: 10.1542/peds.106.4.625.Wong F.Y., Leung T.S., Austin T., Wilkinson M., Meek J.H., Wyatt J.S., et al. Impaired autoregulation in preterm infants identified by using spatially resolved spectroscopy. Pediatrics. 2008;121: e604 e611.Wong F.Y., Leung T.S., Austin T., Wilkinson M., Meek J.H., Wyatt J.S., et al. Impaired autoregulation in preterm infants identified by using spatially resolved spectroscopy. Pediatrics. 2008;121: e604 e611.Peter D.S., Gandy C., Hoffman S.B. Hypotension and adverse outcomes in prematurity: comparing definitions. Neonatology. 2017;111(3):228–33. doi: 10.1159/000452616.Peter D.S., Gandy C., Hoffman S.B. Hypotension and adverse outcomes in prematurity: comparing definitions. Neonatology. 2017;111(3):228–33. doi: 10.1159/000452616.Da Costa C.S., Czosnyka M., Smielewski P., Austin T. Optimal mean arterial blood pressure in extremely preterm infants within the first 24 h of life. J Pediatr. 2018;203:242–8. doi: 10.1016/j.jpeds.2018.07.096.Da Costa C.S., Czosnyka M., Smielewski P., Austin T. Optimal mean arterial blood pressure in extremely preterm infants within the first 24 h of life. J Pediatr. 2018;203:242–8. doi: 10.1016/j.jpeds.2018.07.096.Miall-Allen V.M., de Vries L.S., Whitelaw A.G. Mean arterial blood pressure and neonatal cerebral lesions. Arch Dis Child. 1987;62:1068–9. doi: 10.1136/adc.62.10.1068.Miall-Allen V.M., de Vries L.S., Whitelaw A.G. Mean arterial blood pressure and neonatal cerebral lesions. Arch Dis Child. 1987;62:1068–9. doi: 10.1136/adc.62.10.1068.Vesoulis Z.A., El Ters N.M., Wallendorf M., Mathur A.M. Empirical estimation of the normative blood pressure in infants >28 weeks gestation using a massive data approach. J Perinatol. 2016;369(4):291–5. doi: 10.1038/jp.2015.185.Vesoulis Z.A., El Ters N.M., Wallendorf M., Mathur A.M. Empirical estimation of the normative blood pressure in infants >28 weeks gestation using a massive data approach. J Perinatol. 2016;369(4):291–5. doi: 10.1038/jp.2015.185.Escourrou G., Renesme L., Zana E., Rideau A., Marcoux M.O., Lopez E., et al. How to assess hemodynamic status in very preterm newborns in the first week of life? J Perinatol. 2017;37(9):987–93. doi: 10.1038/jp.2017.57.Escourrou G., Renesme L., Zana E., Rideau A., Marcoux M.O., Lopez E., et al. How to assess hemodynamic status in very preterm newborns in the first week of life? J Perinatol. 2017;37(9):987–93. doi: 10.1038/jp.2017.57.Zubrow A.B., Hulman S., Kushner H., Falkner B. Determinants of blood pressure in infants admitted to neonatal intensive care units: a prospective multicenter study. Philadelphia neonatal blood pressure study group. J Perinatol. 1995;15(6):470–9.Zubrow A.B., Hulman S., Kushner H., Falkner B. Determinants of blood pressure in infants admitted to neonatal intensive care units: a prospective multicenter study. Philadelphia neonatal blood pressure study group. J Perinatol. 1995;15(6):470–9.Vesoulis Z.A., Flower A.A., Zanelli S., Rambhia A., Abubakar M., Whitehead H.V., et al. Blood pressure extremes and severe IVH in preterm infants. Pediatr Res. 2020;87:69–73.Vesoulis Z.A., Flower A.A., Zanelli S., Rambhia A., Abubakar M., Whitehead H.V., et al. Blood pressure extremes and severe IVH in preterm infants. Pediatr Res. 2020;87:69–73.Parati G., Stergiou G.S., Dolan E., Bilo G. Blood pressure variability: clinical relevance and application. J Clin Hypertens (Greenwich). 2018;20(7):1133–7. doi: 10.1111/jch.13304.Parati G., Stergiou G.S., Dolan E., Bilo G. Blood pressure variability: clinical relevance and application. J Clin Hypertens (Greenwich). 2018;20(7):1133–7. doi: 10.1111/jch.13304.Parati G., Ochoa J.E., Lombardi C., Bilo G. Blood pressure variability: assessment, predictive value, and potential as a therapeutic target. Curr Hypertens Rep. 2015;17(4):537–55. doi: 10.1007/s11906-015-0537-1.Parati G., Ochoa J.E., Lombardi C., Bilo G. Blood pressure variability: assessment, predictive value, and potential as a therapeutic target. Curr Hypertens Rep. 2015;17(4):537–55. doi: 10.1007/s11906-015-0537-1.Jiang L.J., Yu Q., Wang F.D., Wu M.F., Liu F., Fu M.F., Gao J.Y., Feng X., Zhang L.F. and Xu Z.X. The role of blood pressure variability indicators combined with cerebral blood flow parameters in predicting intraventricular hemorrhage in very low birth weight preterm infants. Front. Pediatr. 2023;11:1241809. doi: 10.3389/fped.2023.1241809.Jiang L.J., Yu Q., Wang F.D., Wu M.F., Liu F., Fu M.F., Gao J.Y., Feng X., Zhang L.F. and Xu Z.X. The role of blood pressure variability indicators combined with cerebral blood flow parameters in predicting intraventricular hemorrhage in very low birth weight preterm infants. Front. Pediatr. 2023;11:1241809. doi: 10.3389/fped.2023.1241809.Stark M.J., Hodyl N.A., Belegar V.K., Andersen C.C. Intrauterine inflammation, cerebral oxygen consumption and susceptibility to early brain injury in very preterm newborns. Archives of disease in childhood Fetal and neonatal edition. 2016;101: F137–42.Stark M.J., Hodyl N.A., Belegar V.K., Andersen C.C. Intrauterine inflammation, cerebral oxygen consumption and susceptibility to early brain injury in very preterm newborns. Archives of disease in childhood Fetal and neonatal edition. 2016;101: F137–42.Takahashi S., Kakiuchi S., Nanba Y., Tsukamoto K., Nakamura T., Ito Y. The perfusion index derived from a pulse oximeter for predicting low superior vena cava flow in very low birth weight infants. J Perinatol. 2010;30:265–9.Takahashi S., Kakiuchi S., Nanba Y., Tsukamoto K., Nakamura T., Ito Y. The perfusion index derived from a pulse oximeter for predicting low superior vena cava flow in very low birth weight infants. J Perinatol. 2010;30:265–9.Van Laere D., O’Toole J.M., Voeten M., McKiernan J., Boylan G.B., Dempsey E. Decreased Variability and Low Values of Perfusion Index on Day One Are Associated with Adverse Outcome in Extremely Preterm Infants. The Journal of pediatrics. 2016;178:119–24 e1.Van Laere D., O’Toole J.M., Voeten M., McKiernan J., Boylan G.B., Dempsey E. Decreased Variability and Low Values of Perfusion Index on Day One Are Associated with Adverse Outcome in Extremely Preterm Infants. The Journal of pediatrics. 2016;178:119–24 e1.Douglas-Escobar M., Weiss M.D. Biomarkers of brain injury in the premature infant. Front Neurol. 2012;3:185.Douglas-Escobar M., Weiss M.D. Biomarkers of brain injury in the premature infant. Front Neurol. 2012;3:185.Gazzolo D., Vinesi P., Bartocci M., Geloso M.C., Bonacci W., Serra G., et al. Elevated S100 blood level as an early indicator of intraventricular hemorrhage in preterm infants. Correlation with cerebral Doppler velocimetry. J Neurol Sci. 1999;170:32–5.Gazzolo D., Vinesi P., Bartocci M., Geloso M.C., Bonacci W., Serra G., et al. Elevated S100 blood level as an early indicator of intraventricular hemorrhage in preterm infants. Correlation with cerebral Doppler velocimetry. J Neurol Sci. 1999;170:32–5.Gazzolo D., Bruschettini M., Lituania M., Serra G., Bonacci W., Michetti F. Increased urinary S100B protein as an early indicator of intraventricular hemorrhage in preterm infants: correlation with the grade of hemorrhage. Clin Chem. 2001; 47:1836–8.Gazzolo D., Bruschettini M., Lituania M., Serra G., Bonacci W., Michetti F. Increased urinary S100B protein as an early indicator of intraventricular hemorrhage in preterm infants: correlation with the grade of hemorrhage. Clin Chem. 2001; 47:1836–8.Florio P., Gazzolo D., Luisi S., Petraglia F. Activin A in brain injury. Adv Clin Chem. 2007;43:117–30.Florio P., Gazzolo D., Luisi S., Petraglia F. Activin A in brain injury. Adv Clin Chem. 2007;43:117–30.Teramo K.A., Widness J.A. Increased fetal plasma and amniotic fluid erythropoietin concentrations: markers of intrauterine hypoxia. Neonatology. 2009;95:105–16.Teramo K.A., Widness J.A. Increased fetal plasma and amniotic fluid erythropoietin concentrations: markers of intrauterine hypoxia. Neonatology. 2009;95:105–16.Schutyser E., Richmond A., Van Damme J. Involvement of CC chemokine ligand 18 (CCL18) in normal and pathological processes. J Leukoc Biol. 2005;78:14–26.Schutyser E., Richmond A., Van Damme J. Involvement of CC chemokine ligand 18 (CCL18) in normal and pathological processes. J Leukoc Biol. 2005;78:14–26.Amato M., Huppi P., Gambon R., Schneider H. Biochemical timing of peri-intraventricular hemorrhage assessed by perinatal CPK-BB isoenzyme measurements. Journal of perinatal medicine. 1989;17:447–52.Amato M., Huppi P., Gambon R., Schneider H. Biochemical timing of peri-intraventricular hemorrhage assessed by perinatal CPK-BB isoenzyme measurements. Journal of perinatal medicine. 1989;17:447–52.Goddard-Finegold J., Michael L.H. Cerebral blood flow and experimental intraventricular hemorrhage. Pediatr Res. 1984;18(1):7–11.Goddard-Finegold J., Michael L.H. Cerebral blood flow and experimental intraventricular hemorrhage. Pediatr Res. 1984;18(1):7–11.Bada H.S., Hajjar W., Chua C., Sumner D.S. Noninvasive diagnosis of neonatal asphyxia and intraventricular hemorrhage by Doppler ultrasound. J Pediatr. 1979;95(5):775–779.Bada H.S., Hajjar W., Chua C., Sumner D.S. Noninvasive diagnosis of neonatal asphyxia and intraventricular hemorrhage by Doppler ultrasound. J Pediatr. 1979;95(5):775–779.Baik-Schneditz N., Holler N., Urlesberger B., Schwaberger B., Schmolzer G.M., Pichler G. Cerebral Doppler Resistance Index (RI) is associated with regional cerebral oxygenation. Acta Paediatr. 2020;109(11):2299–2301.Baik-Schneditz N., Holler N., Urlesberger B., Schwaberger B., Schmolzer G.M., Pichler G. Cerebral Doppler Resistance Index (RI) is associated with regional cerebral oxygenation. Acta Paediatr. 2020;109(11):2299–2301.Argollo N., Lessa I., Ribeiro S. Cranial Doppler resistance index measurement in preterm newborns with cerebral white matter lesion. J Pediatr. 2006;82(3):221–6. doi: 10.2223/JPED.1488.Argollo N., Lessa I., Ribeiro S. Cranial Doppler resistance index measurement in preterm newborns with cerebral white matter lesion. J Pediatr. 2006;82(3):221–6. doi: 10.2223/JPED.1488.Ikeda T., Amizuka T., Ito Y., Mikami R., Matsuo K., Kawamura N., et al. Changes in the perfusion waveform of the internal cerebral vein and intraventricular hemorrhage in the acute management of extremely lowbirth-weight infants. European journal of pediatrics. 2015;174:331–8.Ikeda T., Amizuka T., Ito Y., Mikami R., Matsuo K., Kawamura N., et al. Changes in the perfusion waveform of the internal cerebral vein and intraventricular hemorrhage in the acute management of extremely lowbirth-weight infants. European journal of pediatrics. 2015;174:331–8.Kluckow M., Evans N. Superior vena cava flow in newborn infants: a novel marker of systemic blood flow. Archives of disease in childhood Fetal and neonatal edition. 2000;82: F182–7.Kluckow M., Evans N. Superior vena cava flow in newborn infants: a novel marker of systemic blood flow. Archives of disease in childhood Fetal and neonatal edition. 2000;82: F182–7.Osborn D.A., Evans N., Kluckow M. Hemodynamic and antecedent risk factors of early and late periventricular/intraventricular hemorrhage in premature infants. Pediatrics. 2003;112:33–9.Osborn D.A., Evans N., Kluckow M. Hemodynamic and antecedent risk factors of early and late periventricular/intraventricular hemorrhage in premature infants. Pediatrics. 2003;112:33–9.Miletin J., Dempsey E.M. Low superior vena cava flow on day 1 and adverse outcome in the very low birthweight infant. Archives of disease in childhood Fetal and neonatal edition. 2008;93: F368–71.Miletin J., Dempsey E.M. Low superior vena cava flow on day 1 and adverse outcome in the very low birthweight infant. Archives of disease in childhood Fetal and neonatal edition. 2008;93: F368–71.Osborn D.A., Evans N., Kluckow M., Bowen J.R., Rieger I. Low superior vena cava flow and effect of inotropes on neurodevelopment to 3 years in preterm infants. Pediatrics. 2007;120:372–80.Osborn D.A., Evans N., Kluckow M., Bowen J.R., Rieger I. Low superior vena cava flow and effect of inotropes on neurodevelopment to 3 years in preterm infants. Pediatrics. 2007;120:372–80.Mercer J.S., Vohr B.R., McGrath M.M., Padbury J.F., Wallach M., Oh W. Delayed cord clamping in very preterm infants reduces the incidence of intraventricular hemorrhage and late-onset sepsis: a randomized, controlled trial. Pediatrics. 2006;117:1235–42.Mercer J.S., Vohr B.R., McGrath M.M., Padbury J.F., Wallach M., Oh W. Delayed cord clamping in very preterm infants reduces the incidence of intraventricular hemorrhage and late-onset sepsis: a randomized, controlled trial. Pediatrics. 2006;117:1235–42.Sommers R., Stonestreet B.S., Oh W., Laptook A., Yanowitz T.D., Raker C., et al. Hemodynamic effects of delayed cord clamping in premature infants. Pediatrics. 2012;129: e667–72.Sommers R., Stonestreet B.S., Oh W., Laptook A., Yanowitz T.D., Raker C., et al. Hemodynamic effects of delayed cord clamping in premature infants. Pediatrics. 2012;129: e667–72.Federico Schena, Rossella Iannotta, Vito D’Andrea, Gaia Francescato,·Alessandra Maye. А novel echocardiography method to assess upper body systemic blood flow in preterm infants and comparison with superior vena cava flow measurement. European Journal of Pediatrics. 2023;182:1839–1845.Federico Schena, Rossella Iannotta, Vito D’Andrea, Gaia Francescato,·Alessandra Maye. А novel echocardiography method to assess upper body systemic blood flow in preterm infants and comparison with superior vena cava flow measurement. European Journal of Pediatrics. 2023;182:1839–1845.Soul J.S., Hammer P.E., Tsuji M., Saul J.P., Bassan H., Limperopoulos C., et al. Fluctuating pressure-passivity is common in the cerebral circulation of sick premature infants. Pediatric research. 2007;61:467–73.Soul J.S., Hammer P.E., Tsuji M., Saul J.P., Bassan H., Limperopoulos C., et al. Fluctuating pressure-passivity is common in the cerebral circulation of sick premature infants. Pediatric research. 2007;61:467–73.O’Leary H., Gregas M.C., Limperopoulos C., Zaretskaya I., Bassan H., Soul J.S., et al. Elevated cerebral pressure passivity is associated with prematurity-related intracranial hemorrhage. Pediatrics. 2009;124:302–9.O’Leary H., Gregas M.C., Limperopoulos C., Zaretskaya I., Bassan H., Soul J.S., et al. Elevated cerebral pressure passivity is associated with prematurity-related intracranial hemorrhage. Pediatrics. 2009;124:302–9.Alderliesten T., Lemmers P.M., Smarius J.J., van de Vosse R.E., Baerts W., van Bel F. Cerebral oxygenation, extraction, and autoregulation in very preterm infants who develop peri-intraventricular hemorrhage. The Journal of pediatrics. 2013;162:698–704 e2.Alderliesten T., Lemmers P.M., Smarius J.J., van de Vosse R.E., Baerts W., van Bel F. Cerebral oxygenation, extraction, and autoregulation in very preterm infants who develop peri-intraventricular hemorrhage. The Journal of pediatrics. 2013;162:698–704 e2.Verma P.K., Panerai R.B., Rennie J.M., Evans D.H. Grading of cerebral autoregulation in preterm and term neonates. Pediatr Neurol. 2000;23:236–242. doi: 10.1016/s0887-8994(00)00184-3.[Support3]Verma P.K., Panerai R.B., Rennie J.M., Evans D.H. Grading of cerebral autoregulation in preterm and term neonates. Pediatr Neurol. 2000;23:236–242. doi: 10.1016/s0887-8994(00)00184-3.[Support3]Noori S., McCoy M., Anderson M.P., Ramji F., Seri I. Changes in cardiac function and cerebral blood flow in relation to peri/intraventricular hemorrhage in extremely preterm infants. The Journal of pediatrics. 2014;164:264–70 e1–3. [Support4]Noori S., McCoy M., Anderson M.P., Ramji F., Seri I. Changes in cardiac function and cerebral blood flow in relation to peri/intraventricular hemorrhage in extremely preterm infants. The Journal of pediatrics. 2014;164:264–70 e1–3. [Support4]Beausoleil T.P., Janaillac M., Barrington K.J., et al. Cerebral oxygen saturation and peripheral perfusion in the extremely premature infant with intraventricular and/ or pulmonary haemorrhage early in life. Sci HYPERLINK «http://dx.doi.org/10.1038/s41598–018–24836–8» Rep. 2018;8:6511.Beausoleil T.P., Janaillac M., Barrington K.J., et al. Cerebral oxygen saturation and peripheral perfusion in the extremely premature infant with intraventricular and/ or pulmonary haemorrhage early in life. Sci HYPERLINK «http://dx.doi.org/10.1038/s41598–018–24836–8» Rep. 2018;8:6511.Vesoulis Z.A., Whitehead H.V., Liao S.M., et al. The hidden consequence of Intraventricular hemorrhage: persistent cerebral desaturation after IVH in Preterm infants. Pediatr Res. 2021;89:869–77.Vesoulis Z.A., Whitehead H.V., Liao S.M., et al. The hidden consequence of Intraventricular hemorrhage: persistent cerebral desaturation after IVH in Preterm infants. Pediatr Res. 2021;89:869–77.Bada H.S., Korones S.B., Perry E.H., Arheart K.L., Ray J.D., Pourcyrous M., et al. Mean arterial blood pressure changes in premature infants and those at risk for intraventricular hemorrhage. The Journal of pediatrics. 1990;117:607–14.Bada H.S., Korones S.B., Perry E.H., Arheart K.L., Ray J.D., Pourcyrous M., et al. Mean arterial blood pressure changes in premature infants and those at risk for intraventricular hemorrhage. The Journal of pediatrics. 1990;117:607–14.Meek J.H., Tyszczuk L., Elwell C.E., Wyatt J.S. Low cerebral blood flow is a risk factor for severe intraventricular haemorrhage. Archives of disease in childhood Fetal and neonatal edition. 1999;81: F15–8.Meek J.H., Tyszczuk L., Elwell C.E., Wyatt J.S. Low cerebral blood flow is a risk factor for severe intraventricular haemorrhage. Archives of disease in childhood Fetal and neonatal edition. 1999;81: F15–8.Vela-Huerta M.M., Amador-Licona M., MedinaOvando N., Aldana-Valenzuela C. Factors associated with early severe intraventricular haemorrhage in very low birth weight infants. Neuropediatrics. 2009;40:224–7.Vela-Huerta M.M., Amador-Licona M., MedinaOvando N., Aldana-Valenzuela C. Factors associated with early severe intraventricular haemorrhage in very low birth weight infants. Neuropediatrics. 2009;40:224–7.Gill A.B., Weindling A.M. Echocardiographic assessment of cardiac function in shocked very low birthweight infants. Arch Dis Child. 1993;68:17–21.Gill A.B., Weindling A.M. Echocardiographic assessment of cardiac function in shocked very low birthweight infants. Arch Dis Child. 1993;68:17–21.Robel-Tillig E., Knüpfer M., Pulzer F., Vogtmann C. Cardiovascular impact of dobutamine in neonates with myocardial dysfunction. Early Hum Dev. 2007; 83:307. DOI: 10.1016/j.earlhumdev.2006.06.005Robel-Tillig E., Knüpfer M., Pulzer F., Vogtmann C. Cardiovascular impact of dobutamine in neonates with myocardial dysfunction. Early Hum Dev. 2007; 83:307. DOI: 10.1016/j.earlhumdev.2006.06.005Rizk M., Lapointe A., Lefebvre F., Barrington K.J. Norepinephrine infusion improves haemodynamics in the preterm infants during septic shock. Acta Paediatr. 2018;107(3):408-413. doi: 10.1111/apa.14112Rizk M., Lapointe A., Lefebvre F., Barrington K.J. Norepinephrine infusion improves haemodynamics in the preterm infants during septic shock. Acta Paediatr. 2018;107(3):408-413. doi: 10.1111/apa.14112Bhombal S., Noori S. Hemodynamic management in chronically ventilated infants. Semin Fetal Neonatal Med. 2019;24:101038.Bhombal S., Noori S. Hemodynamic management in chronically ventilated infants. Semin Fetal Neonatal Med. 2019;24:101038.Ayoub D., Elmashad A., Rowisha M., Eltomey M., El Amrousy D. Hemodynamic effects of high-frequency oscillatory ventilation in preterm neonates with respiratory distress syndrome. Pediatr Pulmonol. 2021;56:424–32.Ayoub D., Elmashad A., Rowisha M., Eltomey M., El Amrousy D. Hemodynamic effects of high-frequency oscillatory ventilation in preterm neonates with respiratory distress syndrome. Pediatr Pulmonol. 2021;56:424–32.Altaany D., Natarajan G., Gupta D., Zidan M., Chawla S. Severe intraventricular hemorrhage in extremely premature infants: are high carbon dioxide pressure or fluctuations the culprit? Am J Perinatol. 2015;32:839–844.Altaany D., Natarajan G., Gupta D., Zidan M., Chawla S. Severe intraventricular hemorrhage in extremely premature infants: are high carbon dioxide pressure or fluctuations the culprit? Am J Perinatol. 2015;32:839–844.

The authors declare that there are no conflicts of interest present.