pediatricjournalАрхив педиатрии и детской хирургииArchives of Pediatrics and Pediatric Surgery2949-46643033-6783НИКИ детства Минздрава Московской области10.31146/2949-4664-apps-2-2-104-115pediatricjournal-48Research ArticleГАСТРОЭНТЕРОЛОГИЯGASTROENTEROLOGYМикробиота кишечника и перспективы применения пробиотиков при целиакии у детейGut microbiota and prospects for probiotics in paediatric celiac diseasehttps://orcid.org/0000-0001-7308-7280ХавкинА. И.KhavkinA. I.gastropedclin@gmail.comhttps://orcid.org/0000-0003-3364-610XЯблоковаЕ. А.YablokovaE. A.noemail@neicon.ruhttps://orcid.org/0000-0002-0364-6785ШаповаловаН. С.ShapovalovaN. S.noemail@neicon.ruhttps://orcid.org/0000-0003-3441-4626ЕрохинаМ. И.ErokhinaM. I.noemail@neicon.ruГосударственное Бюджетное Учреждение Здравоохранения Московской области «Научно-исследовательский клинический институт детства Министерства Здравоохранения Московской области»РоссияResearch Clinical Institute of Childhood, Ministry of Health of the Moscow RegionRussian Federation20230703202412104115Copyright © Хавкин А.И., Яблокова Е.А., Шаповалова Н.С., Ерохина М.И., 20242024Хавкин А.И., Яблокова Е.А., Шаповалова Н.С., Ерохина М.И.Khavkin A.I., Yablokova E.A., Shapovalova N.S., Erokhina M.I.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.nikid.ru/jour/article/view/48

Целиакия - хроническое заболевание, с преимущественным поражением тонкой кишки и провоцируемое употреблением глютена у генетически предрасположенных индивидуумов. Ранее проведённые масштабные исследования позволяют говорить о возможной роли микробиоты кишечника в патогенезе этого заболевания. Изменения качественно-количественных характеристик микробиоты различного генеза могут привести к нарушению регуляции иммунного ответа, что, в свою очередь, может способствовать развитию непереносимости глютена. В этом контексте является актуальным анализ данных об изменении микробиоты кишечника при целиакии и возможности её коррекции пробиотиками, как одной из стратегий лечения детей, страдающих целиакией.

Celiac disease is a chronic disease, with predominant damage to the small intestine and provoked by gluten consumption in genetically predisposed individuals. Previous large-scale studies suggest a possible role of the gut microbiota in the pathogenesis of this disease. Changes in the qualitative and quantitative characteristics of microbiota of different genesis can lead to impaired regulation of immune response, which, in turn, may contribute to the development of gluten intolerance. In this context, it is relevant to analyse the data on changes in the intestinal microbiota in celiac disease and the possibility of its correction with probiotics as one of the strategies for the treatment of children with celiac disease, suffering from celiac disease.

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The authors declare that there are no conflicts of interest present.