<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">pediatricjournal</journal-id><journal-title-group><journal-title xml:lang="ru">Архив педиатрии и детской хирургии</journal-title><trans-title-group xml:lang="en"><trans-title>Archives of Pediatrics and Pediatric Surgery</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2949-4664</issn><issn pub-type="epub">3033-6783</issn><publisher><publisher-name>НИКИ детства Минздрава Московской области</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.31146/2949-4664-apps-1-1-41-49</article-id><article-id custom-type="elpub" pub-id-type="custom">pediatricjournal-9</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES</subject></subj-group></article-categories><title-group><article-title>Сравнительный анализ методов оценки гипертрофии миокарда у детей с артериальной гипертензией</article-title><trans-title-group xml:lang="en"><trans-title>Comparative analysis of methods for evaluating myocardial hypertrophy in children with arterial hypertension</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6444-1871</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Павлинова</surname><given-names>Е. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Pavlinova</surname><given-names>E. B.</given-names></name></name-alternatives><email xlink:type="simple">k140@omgmu.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6459-1976</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Липперт</surname><given-names>В. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Lippert</surname><given-names>V. N.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8390-343X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дакуко</surname><given-names>А. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Dakuko</surname><given-names>A. N.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">Федеральное Государственное Бюджетное Образовательное Учреждение Высшего Образования «Омский государственный медицинский университет» Министерства здравоохранения Российской Федерации; Бюджетное учреждение здравоохранения Омской области «Областная детская клиническая больница»<country>Россия</country></aff><aff xml:lang="en">Omsk State Medical University; Regional Children’s Clinical Hospital<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>09</day><month>10</month><year>2023</year></pub-date><volume>1</volume><issue>1</issue><fpage>41</fpage><lpage>49</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Павлинова Е.Б., Липперт В.Н., Дакуко А.Н., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Павлинова Е.Б., Липперт В.Н., Дакуко А.Н.</copyright-holder><copyright-holder xml:lang="en">Pavlinova E.B., Lippert V.N., Dakuko A.N.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.nikid.ru/jour/article/view/9">https://journal.nikid.ru/jour/article/view/9</self-uri><abstract><p>Актуальность: за последние десятилетия распространенность артериальной гипертензии (АГ) в детской популяции значительно выросла, однако до сих пор остается множество открытых вопросов, связанных с диагностикой и течением заболевания, обоснованностью выбора гипотензивной терапии и рисками поражения органов-мишеней. В клинической практике пациентов с АГ наблюдает команда специалистов различных профилей и не всегда между ними сформирован единый подход в тактике ведения заболевания. Недооценка факторов риска, позднее обнаружение поражений органов-мишеней, несвоевременное начало антигипертензивной терапии существенно повышает риски неблагоприятного, прогрессивного течения болезни, ухудшая дальнейший прогноз. Строгое соблюдение рекомендованных профессиональным сообществом детских кардиологов методов диагностики заболевания и его потенциальных последствий обеспечивает адекватное начало медикаментозной терапии, позволяющей не только контролировать течение АГ, но и профилактировать развитие отдаленных осложнений. Цель: провести анализ показателей, полученных при использовании двух различных формул, применяемых для выявления ремоделирования миокарда левого желудочка у детей с АГ. Материалы и методы: одномоментное, когортное, не рандомизированное исследование, в которое включено 92 пациента с впервые выявленной первичной артериальной гипертензией, на момент обследования не получавших гипотензивную терапию. Оценивались стандартные линейные размеры стенок и полостей сердца при проведении эхокардиографии (ЭхоКГ). Результаты оценивались стандартными критерием Фишера, критерием xi2 в программном обеспечении Statistica 9. Из выборки были исключены дети-спортсмены, пациенты с вторичной АГ, с избытком массы тела, врожденными пороками сердца и кардиомиопатией. Все дети обследованы одинаково согласно действующим федеральным клиническим рекомендациям по «Диагностике и лечению артериальной гипертензии у детей и подростков». Результаты: использование рекомендованной формулы не только достоверно чаще позволяло выявить ранние этапы гипертрофии миокарда ЛЖ, но и отличалось большей чувствительностью. Рутинный метод расчета ремоделирования ЛЖ значительно чаще показывал норму даже при выраженном нарушении геометрии сердца. Заключение: несвоевременное выявление гипертрофии миокарда ЛЖ приводит к позднему началу антигипертензивной терапии, недооценки факторов риска, что повышает риски неблагоприятного течения заболевания и возникновения отдаленных сердечно-сосудистых осложнений в молодом возрасте.</p></abstract><trans-abstract xml:lang="en"><p>Relevance: over the past decades, the prevalence of arterial hypertension (AH) in the pediatric population has increased significantly, but there are still many open questions related to the diagnosis and course of the disease, the validity of the choice of antihypertensive therapy and the risks of target organ injury. In clinical practice, patients with hypertension are observed by a team of specialists of various profiles, and a unified approach to managing the disease is not always formed between them. Underestimation of risk factors, late detection of target organ injury and untimely start of antihypertensive therapy significantly increase the risks of an unfavorable, progressive course of the disease, aggravating the further prognosis. Strict adherence to the methods of diagnosing the disease and its potential consequences recommended by the professional community of pediatric cardiologists ensures an adequate initiation of drug therapy, which allows not only to control the course of hypertension, but also to prevent the development of long-term complications. Objective: to analyze the indicators obtained using the formula recommended by pediatric cardiologists compared to the routine method for detecting left ventricular myocardial remodeling in children with AH. Materials and methods: a cross-sectional, cohort, non-randomized study, which included 92 patients with newly diagnosed primary arterial hypertension, who were not receiving antihypertensive therapy at the time of the examination. The standard linear dimensions of the walls and cavities of the heart were assessed during echocardiography. The results were evaluated by the standard Fisher’s test, the xi2 test in the Statistica 9 software. The sample excluded children-athletes, patients with secondary hypertension, overweight, congenital heart disease and cardiomyopathy. All children were tested the same according to the current Federal Clinical Guidelines “Diagnosis and treatment of arterial hypertension in children and adolescents”. Results: the usage of the recommended formula is not only significantly more often allowed to identify the early stages of LV myocardial hypertrophy, but has great sensitivity. The routine method for calculating LV remodeling showed the norm much more often even in case of severe violation of the geometry of the heart. Conclusion: untimely detection of LV myocardial hypertrophy leads to late initiation of antihypertensive therapy, underestimation of risk factors, which increases the risk of an unfavorable course of the disease and the occurrence of long-term cardiovascular complications at a young age.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>ремоделирование миокарда</kwd><kwd>эхокардиография</kwd><kwd>артериальная гипертензия</kwd><kwd>дети</kwd></kwd-group><kwd-group xml:lang="en"><kwd>myocardial remodeling</kwd><kwd>echocardiography</kwd><kwd>arterial hypertension</kwd><kwd>children</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">González A., Ravassa S., López B. Myocardial remodeling in hypertension: toward a new view of hypertensive heart disease. Hypertension. 2018;72(3): 549-558. doi: 10.1161/HYPERTENSIONAHA.118.11125.</mixed-citation><mixed-citation xml:lang="en">González A., Ravassa S., López B. Myocardial remodeling in hypertension: toward a new view of hypertensive heart disease. Hypertension. 2018;72(3): 549-558. doi: 10.1161/HYPERTENSIONAHA.118.11125.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Cuspidi C., Facchetti R., Bombelli M., Sala C., Tadic M., Grassi G., Mancia G. Risk of mortality in relation to an updated classification of left ventricular geometric abnormalities in a general population: the Pamela study. J Hypertens. 2015;33: 2133-2140. doi: 10.1097/HJH.0000000000000658.</mixed-citation><mixed-citation xml:lang="en">Cuspidi C., Facchetti R., Bombelli M., Sala C., Tadic M., Grassi G., Mancia G. Risk of mortality in relation to an updated classification of left ventricular geometric abnormalities in a general population: the Pamela study. J Hypertens. 2015;33: 2133-2140. doi: 10.1097/HJH.0000000000000658.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Devereux. R. B., Roman M. J. Left ventricular hypertrophy in hypertension: stimuli, patterns, and consequences. Hypertension research: official journal of the Japanese Society of Hypertension. 1999;22(1): 1-9. doi: 10.1291/hypres.22.1.</mixed-citation><mixed-citation xml:lang="en">Devereux. R. B., Roman M. J. Left ventricular hypertrophy in hypertension: stimuli, patterns, and consequences. Hypertension research: official journal of the Japanese Society of Hypertension. 1999;22(1): 1-9. doi: 10.1291/hypres.22.1.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Drazner M. H. The progression of hypertensive heart disease. Circulation. 2011;123: 327-334. doi: 10.1161/CIRCULATIONAHA.108.845792.</mixed-citation><mixed-citation xml:lang="en">Drazner M. H. The progression of hypertensive heart disease. Circulation. 2011;123: 327-334. doi: 10.1161/CIRCULATIONAHA.108.845792.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Elshamaa M. F. Hypertension and hypertensive heart disease in children and adolescents. Clinical Case Reports and Reviews. 2018; 4: 1-12. doi: 10.15761/CCRR.1000384.</mixed-citation><mixed-citation xml:lang="en">Elshamaa M. F. Hypertension and hypertensive heart disease in children and adolescents. Clinical Case Reports and Reviews. 2018; 4: 1-12. doi: 10.15761/CCRR.1000384.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Veronica E., Ina P., Veronica M. Left ventricular remodeling patterns in children with metabolic syndrome. One Health &amp; Risk Management. 2020;1(2), 41-49. doi: 10.1016/j.numecd.2012.04.009.</mixed-citation><mixed-citation xml:lang="en">Veronica E., Ina P., Veronica M. Left ventricular remodeling patterns in children with metabolic syndrome. One Health &amp; Risk Management. 2020;1(2), 41-49. doi: 10.1016/j.numecd.2012.04.009.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Garifulina L., Ashurova M., Goyibova N. Characteristic of the cardiovascular system in children and adolescents at obesity in accompanience of arterial hypertension. European Journal of Molecular and Clinical Medicine. 2020;7 (3):3171.</mixed-citation><mixed-citation xml:lang="en">Garifulina L., Ashurova M., Goyibova N. Characteristic of the cardiovascular system in children and adolescents at obesity in accompanience of arterial hypertension. European Journal of Molecular and Clinical Medicine. 2020;7 (3):3171.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Jing L., Binkley C. M., Suever J. D. Cardiac remodeling and dysfunction in childhood obesity: a cardiovascular magnetic resonance study. Journal of Cardiovascular Magnetic Resonance. 2016;18(1): 1-12. doi: 10.1186/s12968-016-0247-0.</mixed-citation><mixed-citation xml:lang="en">Jing L., Binkley C. M., Suever J. D. Cardiac remodeling and dysfunction in childhood obesity: a cardiovascular magnetic resonance study. Journal of Cardiovascular Magnetic Resonance. 2016;18(1): 1-12. doi: 10.1186/s12968-016-0247-0.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Murdolo G., Angeli F., Reboldi G. Left ventricular hypertrophy and obesity: only a matter of fat? High blood pressure &amp; cardiovascular prevention: the official journal of the Italian Society of Hypertension. 2015;22(1): 29-41. doi: 10.1007/s40292-014-0068-x.</mixed-citation><mixed-citation xml:lang="en">Murdolo G., Angeli F., Reboldi G. Left ventricular hypertrophy and obesity: only a matter of fat? High blood pressure &amp; cardiovascular prevention: the official journal of the Italian Society of Hypertension. 2015;22(1): 29-41. doi: 10.1007/s40292-014-0068-x.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Nadruz W. Myocardial remodeling in hypertension. Journal of human hypertension. 2015;29(1): 1-6. doi: 10.1038/jhh.2014.36.</mixed-citation><mixed-citation xml:lang="en">Nadruz W. Myocardial remodeling in hypertension. Journal of human hypertension. 2015;29(1): 1-6. doi: 10.1038/jhh.2014.36.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Palmieri V., Wachtell K., Gerdts E. Left ventricular function and hemodynamic features of inappropriate left ventricular hypertrophy in patients with systemic hypertension: the LIFE study. American heart journal. 2001;141(5): 784-791. doi: 10.1067/mhj.2001.114803.</mixed-citation><mixed-citation xml:lang="en">Palmieri V., Wachtell K., Gerdts E. Left ventricular function and hemodynamic features of inappropriate left ventricular hypertrophy in patients with systemic hypertension: the LIFE study. American heart journal. 2001;141(5): 784-791. doi: 10.1067/mhj.2001.114803.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Phyllis A.R., Thomas G. D., Grant W. S. Left Ventricular Geometry in Children and Adolescents With Primary Hypertension. American Journal of Hypertension. 2010;23(1): 24-29. doi: 10.1038/ajh.2009.164.</mixed-citation><mixed-citation xml:lang="en">Phyllis A.R., Thomas G. D., Grant W. S. Left Ventricular Geometry in Children and Adolescents With Primary Hypertension. American Journal of Hypertension. 2010;23(1): 24-29. doi: 10.1038/ajh.2009.164.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Tadic M., Cuspidi C. Childhood obesity and cardiac remodeling: from cardiac structure to myocardial mechanics. Journal of Cardiovascular Medicine. 2015;16(8): 538-546. doi: 10.2459/JCM.0000000000000261.</mixed-citation><mixed-citation xml:lang="en">Tadic M., Cuspidi C. Childhood obesity and cardiac remodeling: from cardiac structure to myocardial mechanics. Journal of Cardiovascular Medicine. 2015;16(8): 538-546. doi: 10.2459/JCM.0000000000000261.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Toprak A., Wang H., Chen W. Relation of childhood risk factors to left ventricular hypertrophy (eccentric or concentric) in relatively young adulthood (from the Bogalusa Heart Study). The American journal of cardiology, 2008;101(11): 1621-1625. doi: 10.1016/j.amjcard.2008.01.045.</mixed-citation><mixed-citation xml:lang="en">Toprak A., Wang H., Chen W. Relation of childhood risk factors to left ventricular hypertrophy (eccentric or concentric) in relatively young adulthood (from the Bogalusa Heart Study). The American journal of cardiology, 2008;101(11): 1621-1625. doi: 10.1016/j.amjcard.2008.01.045.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Velagaleti R.S., Gona P., Levy D., Aragam J. Relations of biomarkers representing distinct biological pathways to left ventricular geometry. Circulation. 2008;118: 2252-2258. doi: 10.1161/CIRCULATIONAHA.108.817411.</mixed-citation><mixed-citation xml:lang="en">Velagaleti R.S., Gona P., Levy D., Aragam J. Relations of biomarkers representing distinct biological pathways to left ventricular geometry. Circulation. 2008;118: 2252-2258. doi: 10.1161/CIRCULATIONAHA.108.817411.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Verdecchia P., Angeli F., Mazzotta G. Impact of chamber dilatation on the prognostic value of left ventricular geometry in hypertension. Journal of the American Heart Association, 2017;6(6); 5948. doi: 10.1161/JAHA.117.005948.</mixed-citation><mixed-citation xml:lang="en">Verdecchia P., Angeli F., Mazzotta G. Impact of chamber dilatation on the prognostic value of left ventricular geometry in hypertension. Journal of the American Heart Association, 2017;6(6); 5948. doi: 10.1161/JAHA.117.005948.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Verdecchia P., Angeli F., Borgioni C. Changes in cardiovascular risk by reduction of left ventricular mass in hypertension: a meta-analysis. American Journal of Hypertension. 2003;16(11): 895-899. doi: 10.1016/s0895-7061(03)01018-5.</mixed-citation><mixed-citation xml:lang="en">Verdecchia P., Angeli F., Borgioni C. Changes in cardiovascular risk by reduction of left ventricular mass in hypertension: a meta-analysis. American Journal of Hypertension. 2003;16(11): 895-899. doi: 10.1016/s0895-7061(03)01018-5.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Verdecchia P., Schillaci G., Borgioni C. Prognostic significance of serial changes in left ventricular mass in essential hypertension. Circulation. 1998;97(1): 48-54. doi: 10.1161/01.cir.97.1.48.</mixed-citation><mixed-citation xml:lang="en">Verdecchia P., Schillaci G., Borgioni C. Prognostic significance of serial changes in left ventricular mass in essential hypertension. Circulation. 1998;97(1): 48-54. doi: 10.1161/01.cir.97.1.48.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Verdecchia P., Schillaci G., Borgioni C. Adverse prognostic significance of concentric remodeling of the left ventricle in hypertensive patients with normal left ventricular mass. Journal of the American College of Cardiology, 1995;25(4): 871-878. doi: 10.1016/0735-1097(94)00424-O.</mixed-citation><mixed-citation xml:lang="en">Verdecchia P., Schillaci G., Borgioni C. Adverse prognostic significance of concentric remodeling of the left ventricle in hypertensive patients with normal left ventricular mass. Journal of the American College of Cardiology, 1995;25(4): 871-878. doi: 10.1016/0735-1097(94)00424-O.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Verdecchia P., Schillaci G., Borgioni C. Prognostic value of left ventricular mass and geometry in systemic hypertension with left ventricular hypertrophy. The American journal of cardiology, 1996;78(2): 197-202. doi: 10.1016/s0002-9149(96)90395-1.</mixed-citation><mixed-citation xml:lang="en">Verdecchia P., Schillaci G., Borgioni C. Prognostic value of left ventricular mass and geometry in systemic hypertension with left ventricular hypertrophy. The American journal of cardiology, 1996;78(2): 197-202. doi: 10.1016/s0002-9149(96)90395-1.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Verdecchia P., Angeli F., Mazzotta G. Impact of chamber dilatation on the prognostic value of left ventricular geometry in hypertension. Journal of the American Heart Association, 2017;6(6): 5948. doi: 10.1161/JAHA.117.005948.</mixed-citation><mixed-citation xml:lang="en">Verdecchia P., Angeli F., Mazzotta G. Impact of chamber dilatation on the prognostic value of left ventricular geometry in hypertension. Journal of the American Heart Association, 2017;6(6): 5948. doi: 10.1161/JAHA.117.005948.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Woroniecki R. P., Kahnauth A., Panesar L. E. Left ventricular hypertrophy in pediatric hypertension: a mini review. Frontiers in Pediatrics. 2017;5: 101. doi: 10.3389/fped.2017.00101.</mixed-citation><mixed-citation xml:lang="en">Woroniecki R. P., Kahnauth A., Panesar L. E. Left ventricular hypertrophy in pediatric hypertension: a mini review. Frontiers in Pediatrics. 2017;5: 101. doi: 10.3389/fped.2017.00101.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Aleksandrov A.A., Kisliak O. A., Leontyeva I. V. Clinical guidelines on arterial hypertension diagnosis, treatment and prevention in children and adolescents. Systemic Hypertension. 2020;17(2):7-35. (in Russ.) doi: 10.26442/2075082X.2020.2.200126.@@ Александров А. А., Кисляк О. А., Леонтьева И. В. Диагностика, лечение и профилактика артериальной гипертензии у детей и подростков (клинические рекомендации). Системные гипертензии. 2020;17(2):7-35. doi: 10.26442/2075082X.2020.2.200126.</mixed-citation><mixed-citation xml:lang="en">Aleksandrov A.A., Kisliak O. A., Leontyeva I. V. Clinical guidelines on arterial hypertension diagnosis, treatment and prevention in children and adolescents. Systemic Hypertension. 2020;17(2):7-35. (in Russ.) doi: 10.26442/2075082X.2020.2.200126.@@ Александров А. А., Кисляк О. А., Леонтьева И. В. Диагностика, лечение и профилактика артериальной гипертензии у детей и подростков (клинические рекомендации). Системные гипертензии. 2020;17(2):7-35. doi: 10.26442/2075082X.2020.2.200126.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Baidina A.S., Nosov A.E., Gorbushina O.Yu., Ustinova O.Yu. Improving the diagnostic search for the assessment of left ventricular hypertrophy in men during screening studies. Profilakticheskaya Meditsina. 2022;25(5):67-72. (In Russ.) doi: 10.17116/profmed20222505167. @@ Байдина А. С., Носов А. Е., Горбушина О. Ю. Совершенствование диагностического поиска по оценке гипертрофии левого желудочка у мужчин при скрининговых исследованиях. Профилактическая медицина. 2022;25(5):67-72. doi: 10.17116/profmed20222505167.</mixed-citation><mixed-citation xml:lang="en">Baidina A.S., Nosov A.E., Gorbushina O.Yu., Ustinova O.Yu. Improving the diagnostic search for the assessment of left ventricular hypertrophy in men during screening studies. Profilakticheskaya Meditsina. 2022;25(5):67-72. (In Russ.) doi: 10.17116/profmed20222505167. @@ Байдина А. С., Носов А. Е., Горбушина О. Ю. Совершенствование диагностического поиска по оценке гипертрофии левого желудочка у мужчин при скрининговых исследованиях. Профилактическая медицина. 2022;25(5):67-72. doi: 10.17116/profmed20222505167.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Belov Yu.V., Varaksin V. A. Modern concept of post-infarction remodeling of the left ventricle. RMZ. 2002;10:469. (in Russ.)@@ Белов Ю. В., Вараксин В. А. Современное представление о постинфарктном ремоделировании левого желудочка. РМЖ. 2002;10:469.</mixed-citation><mixed-citation xml:lang="en">Belov Yu.V., Varaksin V. A. Modern concept of post-infarction remodeling of the left ventricle. RMZ. 2002;10:469. (in Russ.)@@ Белов Ю. В., Вараксин В. А. Современное представление о постинфарктном ремоделировании левого желудочка. РМЖ. 2002;10:469.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Kalyuzhin V.V., Teplyakov A. T., Solovtsov M. A. Left ventricular remodeling: one or more scenarios? Bulletin of Siberian medicine. 2016;15(4):120-139. (in Russ.)@@ Калюжин В. В., Тепляков А. Т., Соловцов М. А. Ремоделирование левого желудочка: один или несколько сценариев? Бюллетень сибирской медицины. 2016;15(4):120-139.</mixed-citation><mixed-citation xml:lang="en">Kalyuzhin V.V., Teplyakov A. T., Solovtsov M. A. Left ventricular remodeling: one or more scenarios? Bulletin of Siberian medicine. 2016;15(4):120-139. (in Russ.)@@ Калюжин В. В., Тепляков А. Т., Соловцов М. А. Ремоделирование левого желудочка: один или несколько сценариев? Бюллетень сибирской медицины. 2016;15(4):120-139.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Korovina N.A., Tvorogova T. M., Kuznetsova O. A. Primary arterial hypertension in pediatric practice. RMZ. 2007;1:2. (in Russ.)@@ Коровина Н. А., Творогова Т. М., Кузнецова О. А. Первичная артериальная гипертензия в практике педиатра. РМЖ. 2007;1:2.</mixed-citation><mixed-citation xml:lang="en">Korovina N.A., Tvorogova T. M., Kuznetsova O. A. Primary arterial hypertension in pediatric practice. RMZ. 2007;1:2. (in Russ.)@@ Коровина Н. А., Творогова Т. М., Кузнецова О. А. Первичная артериальная гипертензия в практике педиатра. РМЖ. 2007;1:2.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Kraeva O.A., Bashmakova N. V. Heart remodeling issues. Treatment and prevention. 2020;10(4): 83-88. (in Russ.)@@ Краева О. А., Башмакова Н. В. Вопросы ремоделирования сердца. Лечение и профилактика. - 2020. - Т. 10. - № 4. - С. 83-88.</mixed-citation><mixed-citation xml:lang="en">Kraeva O.A., Bashmakova N. V. Heart remodeling issues. Treatment and prevention. 2020;10(4): 83-88. (in Russ.)@@ Краева О. А., Башмакова Н. В. Вопросы ремоделирования сердца. Лечение и профилактика. - 2020. - Т. 10. - № 4. - С. 83-88.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Ledyaev M. Ya., Dergachev E. S., Svetlova L. V. Arterial hypertension in children and adolescents. Volgograd Scientific Medical Journal. 2009;(4):15-18. (in Russ.)@@ Ледяев М. Я., Дергачев Е. С., Светлова Л. В. Артериальная гипертензия у детей и подростков. Волгоградский научно-медицинский журнал. - 2009. -№ 4. - С. 15-18.</mixed-citation><mixed-citation xml:lang="en">Ledyaev M. Ya., Dergachev E. S., Svetlova L. V. Arterial hypertension in children and adolescents. Volgograd Scientific Medical Journal. 2009;(4):15-18. (in Russ.)@@ Ледяев М. Я., Дергачев Е. С., Светлова Л. В. Артериальная гипертензия у детей и подростков. Волгоградский научно-медицинский журнал. - 2009. -№ 4. - С. 15-18.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Perutsky D.N., Makeeva T. I., Konstantinov S. L. Basic concepts of postinfarction left ventricular myocardial remodeling. Actual problems of medicine. 2011;(10):51-55. (in Russ.)@@ Перуцкий Д. Н., Макеева Т. И., Константинов С. Л. Основные концепции постинфарктного ремоделирования миокарда левого желудочка // Актуальные проблемы медицины. - 2011. - № 10. - С. 51-55.</mixed-citation><mixed-citation xml:lang="en">Perutsky D.N., Makeeva T. I., Konstantinov S. L. Basic concepts of postinfarction left ventricular myocardial remodeling. Actual problems of medicine. 2011;(10):51-55. (in Russ.)@@ Перуцкий Д. Н., Макеева Т. И., Константинов С. Л. Основные концепции постинфарктного ремоделирования миокарда левого желудочка // Актуальные проблемы медицины. - 2011. - № 10. - С. 51-55.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
