Role of progesterone in pregnancy prolongation and its impact on fetal and newborn health. A literature review
https://doi.org/10.66825/2949-4664-apps-3-4-83-92
Abstract
Available foreign and Russian literature underscores the importance of progesterone use for the prolongation and maintenance of pregnancy. However, the number of publications addressing its influence on congenital fetal abnormalities is scarce and the findings remain contradictory. Experimental animal studies have demonstrated the potential impact of progesterone on brain development. The use of progesterone in pregnant women is associated with lower indicators of respiratory distress syndrome, sepsis, pneumonia, retinopathy, and the need for artificial lung ventilation in newborns compared with the general population. The inconsistency and limited availability of reliable data on the health status of newborns following pregnancy prolongation with progesterone therapy, as well as on their adaptive capacity in the early neonatal period, highlight the relevance of this topic and the need for further research into the effects of progesterone therapy on human offspring.
About the Authors
L. V. Malyutina
Research Clinical Institute of Childhood of the Moscow Region; Shchelkovo Perinatal Center of the Ministry of Health of the Moscow Region
Russian Federation
Competing Interests:
Russian Federation
Lyudmila V. Malyutina, Cand. Sci. (Med.), Associate Professor, Leading Researcher at the Department of Neonatal Medicine and Cognitive Development; Deputy Chief Physician for Pediatrics
24a, bldg. 1, Kominterna str., Mytishchi, Moscow region, 141009
b. 6, Parkovaya St., Shchelkovo, 141100
Competing Interests:
The authors declare no conflict of interest.
S. G. Edilyan
Research Clinical Institute of Childhood of the Moscow Region
Russian Federation
Competing Interests:
Russian Federation
Siranush G. Edilyan, Postgraduate Student
24a, bldg. 1, Kominterna str., Mytishchi, Moscow region, 141009
Competing Interests:
The authors declare no conflict of interest.
V. V. Edilyan
Federal State University of Education
Russian Federation
Competing Interests:
Russian Federation
Valentina V. Edilyan, Fifth-Year Student, Faculty of Medicine
10a, bldg. 2, Radio str., Moscow, 105005
Competing Interests:
The authors declare no conflict of interest.
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For citations:
Malyutina L.V., Edilyan S.G., Edilyan V.V. Role of progesterone in pregnancy prolongation and its impact on fetal and newborn health. A literature review. Archives of Pediatrics and Pediatric Surgery. 2025;3(4):83-92. (In Russ.) https://doi.org/10.66825/2949-4664-apps-3-4-83-92
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