Clinical and pathogenetic aspects of low histamine tolerance syndrome
https://doi.org/10.66825/2949-4664-apps-4-1-4-9
Abstract
Purpose of the study. Based on the analysis of modern scientific literature, study the features of clinical manifestations, pathogenesis, diagnosis and treatment of low histamine tolerance syndrome.
Materials and methods. Analysis of modern domestic and foreign scientific literary sources on the problem of impaired tolerance to histamine.
Results. The article presents modern information on histamine intolerance. Pathogenetic mechanisms of syndrome of low tolerance to histamine, features of its clinical manifestations are considered. Particular attention is paid to the diagnosis of this syndrome and the directions of its therapy.
Conclusion. Low histamine tolerance syndrome is a quite common pathology, which, in some cases, is considered by physicians as food allergy. In-depth study of this problem is an urgent task of modern medicine.
About the Authors
A. V. Nalyotov
M. Gorky Donetsk State Medical University
Russian Federation
Competing Interests:
Russian Federation
Andrew V. Nalyotov, Dr. Sci. (Med.), Professor, Head of the Department of Pediatrics № 2
16 Ilyicha av., Donetsk, 283003
Competing Interests:
The authors declare that there is no conflict of interest.
A. I. Khavkin
Research Clinical Institute of Childhood of the Moscow Region; Belgorod State National Research University
Russian Federation
Competing Interests:
Russian Federation
Anatoly I. Khavkin, Dr. Sci. (Med.), Professor, Head of the Moscow Regional Center of Pediatric Gastroenterology and Hepatology of the Research Clinical Institute of Childhood of the Moscow Region; Professor of Department of Pediatrics with a Course in Pediatric Surgical Diseases of Medical Institute of Belgorod State National Research University
Building 1, 24а Kominterna str., Mytishchi, 141009
85 Pobedi str., Belgorod, 308015
Competing Interests:
The authors declare that there is no conflict of interest.
M. A. Matsynina
North-Western State Medical University named after I.I. Mechnikov
Russian Federation
Competing Interests:
Russian Federation
Maria A. Matsynina, Cand. Sci. (Med.), Associate Professor of the Department of Pediatrics and Neonatology
47 Kirochnaya str., Saint Petersburg, 191015
Competing Interests:
The authors declare that there is no conflict of interest.
E. A. Balakireva
Belgorod State National Research University
Russian Federation
Competing Interests:
Russian Federation
Elena A. Balakireva, Dr. Sci. (Med.), Associate Professor, Head of the Department of Pediatrics
85 Pobedi str., Belgorod, 308015
Competing Interests:
The authors declare that there is no conflict of interest.
References
1. Gurova М.М. Food allergy and food intolerance. Children’s medicine of the North-West. 2022; 10 (2): 5–21 (in Russ.).
2. Shreiner E.V., Khavkin A.I., Bystrova V.I., et al. Nutritional aspects of histamine intolerance. Experimental and Clinical Gastroenterology. 2024; (4): 86–93 (in Russ.). DOI: https://DOI.org/10.31146/1682-8658-ecg-224-4-86-93.
3. Shrayner E.V., Khavkin A.I., Bystrova V.I., et al. Study of clinical features of genetic polymorphism of the enzyme diamine oxidase in children and adolescents. Experimental and Clinical Gastroenterology. 2025; (1): 59–64. (in Russ.) DOI: https://DOI. org/10.31146/1682-8658-ecg-233-1-59-64.
4. Comas-Basté O.,Sánchez-Pérez S.,Veciana-Nogués M.T., et al. Histamine intolerance: the current state of the art. Biomolecules. 2020; 10 (8): 1181. DOI: https://DOI.org/10.3390/biom10081181.
5. Nalyotov A.V., Serdyukova D.A., Shapchenko T.I. Histamine intoxication in scombroid poisoning. South Russian Journal of Therapeutic Practice. 2023; 4 (4): 30–33 (in Russ.). DOI: https://DOI.org/10.21886/2712-8156-2023-4-4-30-33.
6. Sánchez-Pérez S., Comas-Basté O., Veciana-Nogués M.T., et al. Low-Histamine Diets: Is the Exclusion of Foods Justified by Their Histamine Content? Nutrients. 2021; 13 (5): 1395. DOI: https://DOI.org/10.3390/nu13051395.
7. Nazar W., Plata-Nazar K., Sznurkowska K., SzlagatysSidorkiewicz A. Histamine Intolerance in Children: A Narrative Review. Nutrients. 2021; 13 (5): 1486. DOI: https://DOI.org/10.3390/nu13051486.
8. Zhao Y., Zhang X., Jin H., et al. Histamine Intolerance – a kind of pseudoallergic reaction. Biomolecules. 2022; 12 (3): 454. DOI: https://DOI.org/10.3390/biom12030454.
9. Burluckaja A.V., Firsova V.N. Histamine intolerance syndrome in children. Kuban Scientific Medical Bulletin. 2017; 24 (4): 185–190 (in Russ.).
10. Turchina M.S., Karaseva Z.V. Low histamine resistance syndrome: cause or consequence of gastrointestinal pathology? Experimental and clinical gastroenterology. 2020; 179 (7): 152–157 (in Russ.). DOI: https://DOI.org/0.31146/1682-8658-ecg-179-7-152-157.
11. Wüthrich B. Allergic and intolerance reactions to wine. Allergol. Select. 2018; 2 (1): 80–88. DOI: https://DOI.org/10.5414/ALX01420E.
12. Colombo F.M., Cattaneo P., Confalonieri E., Bernardi C. Histamine food poisonings: а systematic review and meta-analysis. Crit. Rev. Food Sci. Nutr. 2018; 58: 1131– 1151. DOI: https://DOI.org/10.1080/10408398.2016.1242476.
13. Schink M., Konturek P.C., Tietz E., et al. Microbial patterns in patients with histamine intolerance. J. Physiol. Pharmacol. 2018; 69 (4). DOI: https://DOI.org/10.26402/jpp.2018.4.09.
14. Music E., Korosec P., Silar M., et al. Serum diamineoxidasa activity as a diagnostic test for histamine intolerance. Wien. Kin. Wochenschr. 2013; 125 (9–10): 239–243. DOI: https://DOI.org/10.1007/s00508-013-0354-y.
15. San Mauro Martin I., Brachero S., Garicano Vilar E. Histamine intolerance and dietary management: A complete review. Allergologia et Immunopathologia. 2016; 44 (5): 475–483. DOI: https://DOI.org/10.1016/j.aller.2016.04.015.
16. Son J.H., Chung B.Y., Kim H.O., Park C.W. A histaminefree diet is helpful for treatment of adult patients with chronic spontaneous urticaria. Ann. Dermatol. 2018; 30: 164–172. DOI: https://DOI.org/10.5021/ad.2018.30.2.164.
17. Lackner S., Malcher V., Enko D., et al. Histaminereduced diet and increase of serum diamine oxidase correlating to diet compliance in histamine intolerance. Eur. J. Clin. Nutr. 2019; 73: 102–104. DOI: https://DOI.org/10.1038/s41430-018-0260-5.
Review
For citations:
Nalyotov A.V., Khavkin A.I., Matsynina M.A., Balakireva E.A. Clinical and pathogenetic aspects of low histamine tolerance syndrome. Archives of Pediatrics and Pediatric Surgery. 2026;4(1):4-9. (In Russ.) https://doi.org/10.66825/2949-4664-apps-4-1-4-9
Views:
37
JATS XML
Email this article 