Herpesvirus as a risk factor for recurrent upper respiratory tract infections and other pathological states in children: A clinical case
https://doi.org/10.31146/2949-4664-apps-3-2-72-78
Abstract
The article presents a clinical case of recurrent upper respiratory tract infections (URTI) with a prolonged and complicated course combined with multiple herpesviruses. Cytomegalovirus and human herpes virus type 6 (HHV-6) were diagnosed based on high IgG antibody titers, detection of viral DNA in nasopharyngeal swabs, and HHV-6 DNA in blood. Clinical manifestations included fatigue and gastrointestinal disorders with notably decreased appetite, abdominal pain, and anemia. In accordance with the prescribing information, URTI symptoms were managed with inosine pranobex — a broad-spectrum antiviral drug active against RNA and DNA viruses. The administered therapy significantly improved the patient’s outcome, reducing the frequency of respiratory infections and their complications, likely due to its targeted action against herpes viruses.
Conclusion. The presented clinical case supports the view that when treating children with frequent and complicated upper respiratory tract infections, the potential effect of herpes viruses must be considered. Clarifying the diagnosis enables more appropriate therapeutic decisions and helps improve the child’s health.
About the Authors
A. A. Garbuzov
G.N. Gabrichevsky Research Institute for Epidemiology and Microbiology; City Center for Medical Research
Russian Federation
Russian Federation
Alexander A. Garbuzov, Junior researcher, Clinical Department; City Center for Medical Research
10, Admiral Makarov str., Moscow, 125212
microdistrict 1A, Severnoye Chertanovo, Moscow, 117648
T. A. Ruzhentsova
Moscow Medical University “Reaviz”
Russian Federation
Russian Federation
Tatiana A. Ruzhentsova, Dr. Sci. (Med.), Head of Department of Internal Medicine, Head of Department of Clinical Medicine
Scopus Author ID 57193900159
2, bldg. 2, Krasnobogatyrskaya str., Moscow, 107564
A. L. Bayrakova
G.N. Gabrichevsky Research Institute for Epidemiology and Microbiology; Russian University of Medicine (ROSUNIMED)
Russian Federation
Russian Federation
Alexandra L. Bayrakova, Cand. Sci. (Biol.), Leading researcher, Laboratory of Clinical Microbiology and Biotechnology; Assist. Prof., Department of Clinical Microbiology and Phage Therapy
10, Admiral Makarov str., Moscow, 125212
4, Dolgorukovskaya str., Moscow, 127006
S. S. Saidov
Kaluga Oblast Specialized Center for Infectious Diseases and AIDS
Russian Federation
Russian Federation
Saidmurod S. Saidov, Dr. Sci. (Med.), Prof., Chief Medical Offi cer
115, bldg. 3, Grabtsevskoye Shosse, Kaluga, 248009
D. Sh. Macharadze
G.N. Gabrichevsky Research Institute for Epidemiology and Microbiology
Russian Federation
Russian Federation
Dali Sh. Macharadze, Dr. Sci. (Med.), Leading researcher, Clinical Department
10, Admiral Makarov str., Moscow, 125212
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For citations:
Garbuzov A.A., Ruzhentsova T.A., Bayrakova A.L., Saidov S.S., Macharadze D.Sh. Herpesvirus as a risk factor for recurrent upper respiratory tract infections and other pathological states in children: A clinical case. Archives of Pediatrics and Pediatric Surgery. 2025;3(2):72-78. (In Russ.) https://doi.org/10.31146/2949-4664-apps-3-2-72-78
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